> Source: https://www.thenycoptometrist.com/blog/accutane-dry-eyes-treatment (last updated 2026-04-14)

# Accutane and Dry Eyes: Why It Happens and How to Find Relief

**By Dr. Joanna Latek OD** · Published 2026-04-14

> Struggling with dry eyes while taking Accutane? Learn why isotretinoin causes dryness, common symptoms, and evidence-based treatments to keep your eyes comfortable.

## **Accutane \(Isotretinoin\) and Your Eyes**

Isotretinoin—commonly known as Accutane—is one of the most effective treatments for severe acne. However, while it can dramatically improve skin, it frequently causes **ocular side effects**, with **dry eye disease** being the most common.

If you are experiencing burning, irritation, or blurry vision while on Accutane, you are not alone—this is a well-documented and expected side effect.

## **Why Does Accutane Cause Dry Eyes?**

Accutane works by shrinking sebaceous glands to reduce oil production in the skin. Unfortunately, it also affects the **meibomian glands** in your eyelids, which are responsible for producing the oily layer of your tear film.

Recent studies \(2021–2026\) show that isotretinoin can:

- Decrease **meibomian gland secretion**
- Alter **tear film stability**
- Increase **tear evaporation**
- Induce **inflammation of the ocular surface**

The result is **evaporative dry eye**, often with a component of **meibomian gland dysfunction \(MGD\)**.

## **Common Symptoms Patients Notice**

Patients on Accutane often report:

- Dryness or grittiness
- Burning or stinging
- Redness
- Fluctuating or blurry vision
- Contact lens intolerance
- Increased sensitivity to light

Symptoms can begin **within weeks of starting treatment** and may worsen over time.

## **Is the Damage Permanent?**

In most cases, dry eye symptoms improve after stopping Accutane. However, newer research suggests:

- Some patients develop **long-term or chronic dry eye**
- Meibomian gland changes may be **partially irreversible** in certain cases
- Risk increases with **higher doses and longer treatment duration**

This is why **early intervention matters**.

## **Who Is at Higher Risk?**

You may be more likely to develop significant dry eye if you:

- Already have **dry eye disease**
- Wear **contact lenses**
- Spend long hours on screens
- Have underlying conditions like Meibomian Gland Dysfunction
- Live in dry or high-airflow environments \(e.g., offices with AC/heat\)

## **How to Manage Dry Eyes on Accutane**

The goal is to **stabilize the tear film and protect the ocular surface** while you complete your course of treatment.

### **1. Use High-Quality Artificial Tears**

- Preservative-free tears are preferred \(see Dry Eye & Allergy treatment guide for recommendations\)
- Use **at least 2–4x daily**, even if symptoms are mild

### **2. Support the Meibomian Glands**

- Warm compresses \(5–10 minutes daily\)
- Lid hygiene \(gentle cleansers or wipes\)

### **3. Consider Omega-3 Supplementation**

Evidence suggests omega-3 fatty acids may help improve tear stability and reduce inflammation.

### **4. Limit Contact Lens Wear**

Many patients develop intolerance during treatment. Temporary reduction or switching to glasses can help significantly.

### **5. Prescription Treatments \(When Needed\)**

For moderate to severe symptoms, your eye doctor may recommend:

- Cyclosporine ophthalmic emulsion
- Lifitegrast
- Short-term topical steroids \(carefully monitored\)

These treatments target **inflammation**, not just lubrication.

### **6. In-Office Treatments**

If symptoms persist, procedures like:

- Meibomian gland expression
- Thermal pulsation \(e.g., LipiFlow\)
- Intense pulsed light \(IPL\)

may be considered to restore gland function.

## **When Should You See an Eye Doctor?**

You should schedule an evaluation if you experience:

- Persistent dryness despite using artificial tears
- Blurry vision that fluctuates
- Difficulty wearing contact lenses
- Redness or irritation that worsens

Early management can prevent long-term complications.

## **Key Takeaway**

Accutane is highly effective—but it comes with real, measurable effects on the ocular surface. The good news is that **with proactive care, most patients can stay comfortable throughout treatment**.

If you are starting Accutane or already noticing symptoms, a baseline and follow-up eye exam can make a significant difference in protecting your long-term eye health.

## 

1. Aragona, P., et al. “Effects of Isotretinoin on Meibomian Glands and Tear Film.” _International Ophthalmology_, 2022.
2. Wang, M. T. M., et al. “Systemic Medications and Dry Eye Disease.” _Ocular Surface_, 2021.
3. Egger, S. F., et al. “Ocular Side Effects of Isotretinoin Therapy.” _Cornea_, 2023.
4. Zhang, X., et al. “Impact of Oral Isotretinoin on Tear Film and Ocular Surface.” _BMC Ophthalmology_, 2024.
5. Liu, R., et al. “Meibomian Gland Dysfunction and Systemic Retinoids.” _American Journal of Ophthalmology_, 2022.